R&D

Novel drug liberates tumour vessels to aid cancer drug delivery

A therapeutic antibody developed by scientists at UCL has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments.

The findings in mice, published in the journal MED, are the first to demonstrate that inhibiting the activity of LRG1, a protein produced in many tumorous tissues, liberates disorganised angiogenesis (blood vessel formation) - a leading cause of morbidity in numerous diseases including cancer.

Researchers reveal a strategy for next-generation COVID-19 vaccines

A study led by the Garvan Institute of Medical Research has revealed a guide to developing COVID-19 vaccines that both prevent the coronavirus from infecting human cells and that are more resistant to evolving viral strains.

The team’s key criteria for antibodies generated by future vaccines are to target regions of the SARS-CoV-2 viral surface that are unlikely to mutate and share key features that the researchers found could block the virus from infecting human cells.

Cleveland Clinic launches first-of-its kind preventive breast cancer vaccine study

Cleveland Clinic researchers have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body's immune response.

Needle-free COVID-19 vaccine shows promise

A needle-free COVID-19 vaccination could be possible, with University of Queensland scientists successfully protecting mice from the virus by administering a US-developed vaccine candidate with a ‘patch’.

The University of Texas Hexapro vaccine candidate - delivered via the UQ-developed and Vaxxas-commercialised high-density microarray patch (HD-MAP) - provided protection against COVID-19 disease with a single, pain-free 'click' from a pocket-sized applicator.

New computer modelling could boost drug discovery

Scientists from Queen's University Belfast have developed a computer-aided data tool that could improve treatment for a range of illnesses.

The computer modelling tool will predict novel sites of binding for potential drugs that are more selective, leading to more effective drug targeting, increasing therapeutic efficacy and reducing side effects.

High effectiveness of mix-and-match COVID-19 vaccines

People who had received a first dose of the Oxford-AstraZeneca COVID-19 vaccine and received an mRNA vaccine for their second dose had a lower risk of infection compared to people who had received both doses of the Oxford-AstraZeneca vaccine. This is shown in a nationwide study performed by researchers at Umeå University, Sweden.

One coronavirus vaccine may protect against other coronaviruses

Northwestern Medicine scientists have shown for the first time that coronavirus vaccines and prior coronavirus infections can provide broad immunity against other, similar coronaviruses. The findings build a rationale for universal coronavirus vaccines that could prove useful in the face of future epidemics.

Research & Development

Novel drug liberates tumour vessels to aid cancer drug delivery

Researchers reveal a strategy for next-generation COVID-19 vaccines

Cleveland Clinic launches first-of-its kind preventive breast cancer vaccine study

Needle-free COVID-19 vaccine shows promise

New computer modelling could boost drug discovery

High effectiveness of mix-and-match COVID-19 vaccines

One coronavirus vaccine may protect against other coronaviruses

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