R&D

Paxlovid substantially reduced risk of hospitalization, death during Omicron wave

Nirmatrelvir-ritonavir (Paxlovid) significantly reduced the likelihood of hospitalization or death from COVID-19 in people at risk of severe illness, according to new research in CMAJ (Canadian Medical Association Journal).

The study, conducted by Ontario researchers, aimed to evaluate the effectiveness of nirmatrelvir–ritonavir in preventing severe illness during the emergence of the Omicron variant.

Scientists pinpoint protein that helps cancer-causing viruses evade immune response

The viruses Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) have been linked to several cancers. For the first time, UNC School of Medicine scientists have discovered that these viruses use a human protein called barrier-to-autointegration factor 1, or BAF, to evade our innate immune response, allowing the viruses to spread and cause disease.

Antidepressants used for chronic pain on the rise, but are they effective?

New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.

Many people are unaware that some antidepressants (medications used to treat people living with depression) are also being prescribed to treat certain chronic pain conditions.

Discovery of anti-cancer chemistry makes skullcap fit for modern medicine

The evolutionary secrets that enable the medicinal herb known as barbed skullcap to produce cancer fighting compounds have been unlocked by a collaboration of UK and Chinese researchers.

The CEPAMS collaboration used DNA sequencing technology to assemble the genomic sequence of skullcap (Scutellaria barbata) known in China as banzhilian.

A soybean protein blocks LDL cholesterol production, reducing risks of metabolic diseases

A protein in soybeans blocks the production of a liver enzyme involved in the metabolism of triglycerides and low-density lipoprotein, scientists found in a recent study.

Consuming soy flour rich in the protein B-conglycinin has the potential to reduce LDL cholesterol levels and lower the risk of metabolic diseases such as atherosclerosis and fatty liver disease,

Nanotechnology may improve gene therapy for blindness

Using nanotechnology that enabled mRNA-based COVID-19 vaccines, a new approach to gene therapy may improve how physicians treat inherited forms of blindness.

A collaborative team of researchers with Oregon Health & Science University and Oregon State University have developed an approach that uses lipid nanoparticles - tiny, lab-made balls of fat - to deliver strands of messenger ribonucleic acid, or mRNA, inside the eye.

Scientists develop a cancer vaccine to simultaneously kill and prevent brain cancer

Scientists are harnessing a new way to turn cancer cells into potent, anti-cancer agents. In the latest work from the lab of Khalid Shah, MS, PhD, at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, investigators have developed a new cell therapy approach to eliminate established tumors and induce long-term immunity, training the immune system so that it can prevent cancer from recurring.

Research & Development

Paxlovid substantially reduced risk of hospitalization, death during Omicron wave

Scientists pinpoint protein that helps cancer-causing viruses evade immune response

Antidepressants used for chronic pain on the rise, but are they effective?

Discovery of anti-cancer chemistry makes skullcap fit for modern medicine

A soybean protein blocks LDL cholesterol production, reducing risks of metabolic diseases

Nanotechnology may improve gene therapy for blindness

Scientists develop a cancer vaccine to simultaneously kill and prevent brain cancer

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