R&D

Antibody-based eye drops show promise for treating dry eye disease

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid. They are also the first to demonstrate that patients with dry eye disease experienced reduced signs and symptoms of the condition in response to a new eye drop treatment - made from pooled human antibodies - that targets ACPAs.

AI and big data predict which research will influence future medical treatments

An artificial intelligence/machine learning model to predict which scientific advances are likely to eventually translate to the clinic has been developed by Ian Hutchins and colleagues in the Office of Portfolio Analysis (OPA), a team led by George Santangelo at the National Institutes of Health (NIH). This work, described in a Meta-Research article published October 10 in the open-access journal PLOS Biology,

Pharmacists provide patient value in team-based care

With inhaler in hand, Dr. Cheng Yuet went over every detail to make sure the patient understood how the drug would control their COPD symptoms. Dr. Yuet is proving what a difference it makes when pharmacists are integrated into the health care team. As part of an innovative model being used at UNT Health Science Center, Dr. Yuet and three other pharmacists manage the care of patients with chronic diseases such as asthma, diabetes and hypertension.

Cancer patients who exercise have less heart damage from chemotherapy

Patients with cancer should receive a tailored exercise prescription to protect their heart, reports a paper published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).

Cardiovascular diseases are common side effects in patients with cancer.

Discovery of new source of cancer antigens may expand cancer vaccine capabilities

For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University's Biodesign Institute have pooled their energies into an often scoffed-at, high-risk, high-reward goal in medicine: to develop a universal vaccine to prevent cancer.

A brain protein that could put the brakes on Alzheimer's

University of California, Irvine biologists blazing new approaches to studying Alzheimer's have made a major finding on combating inflammation linked to the disease. The School of Biological Sciences researchers' discovery about the role of a protein called TOM-1 heralds a shift toward examining the molecular underpinnings of Alzheimer's processes. Their paper has just been published in Proceedings of the National Academy of Sciences.

Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function

Genome-wide association studies have uncovered more than 500 genetic variants linked to heart function, everything from heart rate to irregular rhythms that can lead to stroke, heart failure or other complications. But since most of these variations fall into areas of the genome that don't encode proteins, exactly how they influence heart function has remained unclear.

Research & Development

Antibody-based eye drops show promise for treating dry eye disease

AI and big data predict which research will influence future medical treatments

Pharmacists provide patient value in team-based care

Cancer patients who exercise have less heart damage from chemotherapy

Discovery of new source of cancer antigens may expand cancer vaccine capabilities

A brain protein that could put the brakes on Alzheimer's

Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function

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