Through analysis of the human genome, Basle scientists have identified molecules and compounds that are related to human memory. In a subsequent pharmacological study with one of the identified compounds, the scientists found a drug-induced reduction of aversive memory. This could have implications for the treatment of posttraumatic stress disorder, which is characterized by intrusive traumatic memories. The findings have been published in the latest edition of the magazine PNAS. In the last decade, the human genome project has led to an unprecedented rate of discovery of genes related to humane disease. However, so far it has not been clear to what extent this knowledge can be used for the identification of new drugs, especially in the field of neuropsychiatric disorders.
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Bacteria-eating viruses 'magic bullets in the war on superbugs'
A specialist team of scientists from the University of Leicester has isolated viruses that eat bacteria - called phages - to specifically target the highly infectious hospital superbug Clostridium difficile (C. diff). Now an exciting new collaboration between the University of Leicester, the University of Glasgow and AmpliPhi Biosciences Corporation could lead to the use of bacteriophages for treating the superbug Clostridium difficile infections. Dr Martha Clokie, from the University of Leicester's Department of Infection, Immunity and Inflammation has been investigating an alternative approach to antibiotics, which utilizes naturally occurring viruses called bacteriophages, meaning 'eaters of bacteria'.
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Lung infections offer clue to unlocking the mystery of life-saving heart drug
Scientists from the University of Sheffield have discovered ground breaking clues as to how the pioneering heart drug ticagrelor might reduce the risk of dying following a heart attack, in comparison to previous standard treatments. The new findings, published in Platelets, show that ticagrelor may reduce the risk of dying as a result of a lung infection after suffering a heart attack compared to patients treated with the drug clopidogrel. The analysis, which was led by researchers from the University of Sheffield and Uppsala University Sweden, is the latest to come from the PLATO study which originally included over 18,000 patients worldwide.
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New 3D method used to grow miniature pancreas
An international team of researchers from the University of Copenhagen have successfully developed an innovative 3D method to grow miniature pancreas from progenitor cells. The future goal is to use this model to help in the fight against diabetes. The research results has just been published in the scientific journal Development. Professor Anne Grapin-Botton and her team at the Danish Stem Cell Centre have developed a three-dimensional culture method which enables the efficient expansion of pancreatic cells. The new method allows the cell material from mice to grow vividly in picturesque tree-like structures. The method offers huge long term potential in producing miniature human pancreas from human stem cells.
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Research on alternative testing methods contributes to improving the overall welfare of animals
One of the central demands of the animal activists is to abolish animal testing and to use alternative testing methods instead. In this context, the European Union has taken a huge step forward at the beginning of this year: On March 11 a full ban on the marketing of cosmetics and hygiene products tested on animals entered into force in the EU. The search for alternative testing methods for safety assessment is thus more pressing than ever. The development of such non-animal testing methods, especially when it comes to reliably predicting long-term toxic effects, represents a major scientific challenge. The NOTOX project, which is co-funded by the European Commission and Cosmetics Europe, the European trade association of the cosmetics industry, significantly contributes to this endeavor by developing and validating predictive bioinformatics models characterizing long-term toxicity responses.
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The Nobel Prize in Physiology or Medicine 2013
The Nobel Assembly at Karolinska Institutet has today decided to award The 2013 Nobel Prize in Physiology or Medicine jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells. The 2013 Nobel Prize honours three scientists who have solved the mystery of how the cell organizes its transport system. Each cell is a factory that produces and exports molecules. For instance, insulin is manufactured and released into the blood and chemical signals called neurotransmitters are sent from one nerve cell to another. These molecules are transported around the cell in small packages called vesicles. The three Nobel Laureates have discovered the molecular principles that govern how this cargo is delivered to the right place at the right time in the cell.
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New web portal for drug discovery
Researchers can now use the GRANATUM web portal to socially interact and cooperate, build and share hypotheses, search databases, design and execute in-silico experiments to screen potential chemoprevention drugs ahead of in-vitro and in-vivo test. It is ready to connect biomedical researchers and provide access to information about cancer research and established pharmaceutical agents from 83 global data sources in an integrated, semantically interlinked manner. The European GRANATUM project started two years ago. Mission: to build a collaboration platform for biomedical researchers in the field of cancer drug research.
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