Blueberries are rich in flavonoids, which possess antioxidant and anti-inflammatory properties.
Dr Joanna Bowtell, head of Sport and Health Sciences at the University of Exeter, said: "Our cognitive function tends to decline as we get older, but previous research has shown that cognitive function is better preserved in healthy older adults with a diet rich in plant-based foods.
"In this study we have shown that with just 12 weeks of consuming 30ml of concentrated blueberry juice every day, brain blood flow, brain activation and some aspects of working memory were improved in this group of healthy older adults."
Of the 26 healthy adults in the study, 12 were given concentrated blueberry juice - providing the equivalent of 230g of blueberries - once a day, while 14 received a placebo.
Before and after the 12-week period, participants took a range of cognitive tests while an MRI scanner monitored their brain function and resting brain blood flow was measured.
Compared to the placebo group, those who took the blueberry supplement showed significant increases in brain activity in brain areas related to the tests.
The study excluded anyone who said they consumed more than five portions of fruit and vegetables per day, and all participants were told to stick to their normal diet throughout.
Previous research has shown that risk of dementia is reduced by higher fruit and vegetable intake, and cognitive function is better preserved in healthy older adults with a diet rich in plant-based foods.
Flavonoids, which are abundant in plants, are likely to be an important component in causing these effects.
The research was carried out in association with the University of the West of England, and the concentrated blueberry juice (BlueberryActive) and some funding for the study was provided by CherryActive Ltd, which produces cherry, beetroot and blueberry products in concentrate and capsule form.
The study was also supported by the charity BRACE, which raises funds to support dementia research.
Bowtell JL, Aboo-Bakkar Z, Conway M, Adlam AR, Fulford J.
Enhanced task related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation.
Appl Physiol Nutr Metab. 2017 Mar 1. doi: 10.1139/apnm-2016-0550.