A promising treatment for an incurable, deadly kidney disease
A potential treatment for polycystic kidney disease - a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure - has shown promising results in animal testing. A study describing the drug's development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in afflicted mice following treatment.
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New drug may protect against memory loss in Alzheimer's disease
A new drug discovered through a research collaboration between the University at Buffalo and Tetra Therapeutics may protect against memory loss, nerve damage and other symptoms of Alzheimer's disease. Preclinical research found that the drug - called BPN14770 - deters the effects of amyloid beta, a hallmark protein of Alzheimer's that is toxic to nerve cells.
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Breast cancer can form 'sleeper cells' after drug treatment
Breast cancer medicines may force some cancer cells into 'sleeper mode', allowing them to potentially come back to life years after initial treatment. These are the early-stage findings from scientists at Imperial College London, who studied human breast cancer cells in the laboratory.
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Experimental validation confirms the ability of artificial intelligence to accelerate drug discovery
Insilico Medicine, a global leader in artificial intelligence for drug discovery, today announced the publication of a paper titled, "Deep learning enables rapid identification of potent DDR1 kinase inhibitors," in Nature Biotechnology. The paper describes a timed challenge, where the new artificial intelligence system called Generative Tensorial Reinforcement Learning (GENTRL) designed six novel inhibitors of DDR1, a kinase target implicated in fibrosis and other diseases, in 21 days.
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A new drug could revolutionize the treatment of neurological disorders
The international team of scientists from Gero Discovery LLC, the Institute of Biomedical Research of Salamanca, and Nanosyn, Inc. has found a potential drug that may prevent neuronal death through glucose metabolism modification in stressed neurons. The positive results obtained in mice are rather promising for future use in humans.
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Interactions discovered in cells insulating nerve pathways
Schwann cells form a protective sheath around nerve fibres and ensure that nerve impulses are transmitted rapidly. If these cells are missing or damaged, severe neurological diseases may occur as a result. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in demonstrating a complex interaction within Schwann cells which plays an important role for correct cell maturation.
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Preventing tumor metastasis
Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an agent against the metastasis of certain cancers. Using the Swiss Light Source, they deciphered the structure of a receptor that plays a crucial role in the migration of cancer cells.
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