Research

Remdesivir reduces COVID-19 mortality in a real-world setting

The COVID-19 pandemic has led to an explosion of clinical research resulting in the development of a variety of vaccines and treatments, although the efficacy of some remains controversial. Now, researchers from Japan report that remdesivir, a drug whose effectiveness has been debated, appears to make a big difference in Japanese patients with COVID-19 who received corticosteroids in the ICU.

Pocket feature shared by deadly coronaviruses could lead to pan-coronavirus antiviral treatment

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now. Researchers of the University of Bristol-led study, published in Science Advances today, say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses - from the 2002 SARS-CoV outbreak to Omicron, the current variant of SARS-CoV-2, as well as dangerous variants that may emerge in future.

Machine learning can help predict patient response to cancer immunotherapy

Predicting which patients will respond well to treatment is a quandary that has plagued the field of cancer immunotherapy for more than four decades. Now, researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy are one step closer to solving that problem.

Making melanoma immortal: Pitt scientists discover key genetic step in cancer’s race to live forever

Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality.

In a paper published in Science this week, Jonathan Alder, Ph.D. and his team describe how they discovered the perfect combination of genetic alterations that tumors use to promote explosive growth and prevent their own demise, a development that could change the way oncologists understand and treat melanoma.

Study reveals vaccine confidence declined considerably during COVID-19 pandemic

A new study suggests that, despite the success of the COVID-19 vaccination campaigns, vaccine confidence has declined significantly since the start of the pandemic.

Researchers from the University of Portsmouth carried out two anonymous surveys in the winters of 2019 and 2022 to investigate people's attitudes towards vaccinations and the factors that might underpin hesitancy and refusal.

Novel derivative of "love hormone" oxytocin improves cognitive impairment in Alzheimer's

The cognitive decline and memory loss observed in Alzheimer's disease (AD) is attributed to the accumulation of β-amyloid protein (Aβ), which impairs neural function in the brain. Experimentation has shown that oxytocin, a peptide hormone primarily responsible for parturition, bonding, and lactation, also regulates cognitive behavior in the rodent central nervous system (CNS).

Protein IDs, drug candidates, show promise for COVID science

A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.

Research & Development

Remdesivir reduces COVID-19 mortality in a real-world setting

Pocket feature shared by deadly coronaviruses could lead to pan-coronavirus antiviral treatment

Machine learning can help predict patient response to cancer immunotherapy

Making melanoma immortal: Pitt scientists discover key genetic step in cancer’s race to live forever

Study reveals vaccine confidence declined considerably during COVID-19 pandemic

Novel derivative of "love hormone" oxytocin improves cognitive impairment in Alzheimer's

Protein IDs, drug candidates, show promise for COVID science

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